PoplarV1, Main, Exploration, bibRecord, 001320

LC-ESI-MS/MS Identification of Biologically Active Phenolic Compounds in Mistletoe Berry Extracts from Different Host Trees.

Identifieur interne : 001320 ( Main/Exploration ); précédent : 001319; suivant : 001321

LC-ESI-MS/MS Identification of Biologically Active Phenolic Compounds in Mistletoe Berry Extracts from Different Host Trees.

Auteurs : Wioleta Pietrzak [Pologne] ; Renata Nowak [Pologne] ; Urszula Gawlik-Dziki [Pologne] ; Marta Kinga Lemieszek [Pologne] ; Wojciech Rzeski [Pologne]

Source :

Molecules (Basel, Switzerland) [ 1420-3049 ] ; 2017.

RBID : pubmed:28417943

Descripteurs français

English descriptors

KwdEn :
- Antineoplastic Agents, Phytogenic (chemistry), Antineoplastic Agents, Phytogenic (pharmacology), Antioxidants (chemistry), Antioxidants (pharmacology), Chromatography, Liquid (MeSH), Free Radical Scavengers (chemistry), Free Radical Scavengers (pharmacology), Fruit (chemistry), Humans (MeSH), Mistletoe (chemistry), Phenols (chemistry), Phytochemicals (chemistry), Plant Extracts (chemistry), Plant Extracts (pharmacology), Spectrometry, Mass, Electrospray Ionization (MeSH), Tandem Mass Spectrometry (MeSH).
MESH :
- chemical , chemistry : Antineoplastic Agents, Phytogenic, Antioxidants, Free Radical Scavengers, Phenols, Phytochemicals, Plant Extracts.
- chemical , pharmacology : Antineoplastic Agents, Phytogenic, Antioxidants, Free Radical Scavengers, Plant Extracts.
- chemistry : Fruit, Mistletoe.
- Chromatography, Liquid, Humans, Spectrometry, Mass, Electrospray Ionization, Tandem Mass Spectrometry.

Abstract

A new, rapid, sensitive and selective liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) method was developed to determine the content of flavonoid aglycones and phenolic acids in mistletoe berries (Viscum album L.) harvested from six different Polish host trees. Additionally, the total phenolic content (TPC) and total flavonoid content (TFC) as well as an antioxidant and antiproliferative activity were evaluated for the first time. The plant material was selectively extracted using ultrasound assisted maceration with methanol/water (8:2) solution. The obtained TPC and TFC results varied from 7.146 to 9.345 mg GA g^-¹ and from 1.888 to 2.888 mg Q g^-1 of dry extracts, respectively. The LC-ESI-MS/MS analysis demonstrated the highest content of phenolic acids in mistletoe berries from Populus nigra 'Italica' L. and flavonoid aglycones in mistletoe berries from Tilia cordata Mill. (354.45 µg and 5.955 µg per g dry extract, respectively). The moderate antioxidant activity of investigated extracts was obtained. The studies revealed that the examined extracts decreased the proliferation of human colon adenocarcinoma cells line LS180 in a dose-dependent manner without cytotoxicity in the human colon epithelial cell line CCD 841 CoTr. Moreover, the obtained results suggest considerable impact of polyphenols on the anticancer activity of these extracts.

DOI: 10.3390/molecules22040624
PubMed: 28417943
PubMed Central: PMC6154606

Affiliations:

Pologne

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<term>Antioxidants (chemistry)</term>
<term>Antioxidants (pharmacology)</term>
<term>Chromatography, Liquid (MeSH)</term>
<term>Free Radical Scavengers (chemistry)</term>
<term>Free Radical Scavengers (pharmacology)</term>
<term>Fruit (chemistry)</term>
<term>Humans (MeSH)</term>
<term>Mistletoe (chemistry)</term>
<term>Phenols (chemistry)</term>
<term>Phytochemicals (chemistry)</term>
<term>Plant Extracts (chemistry)</term>
<term>Plant Extracts (pharmacology)</term>
<term>Spectrometry, Mass, Electrospray Ionization (MeSH)</term>
<term>Tandem Mass Spectrometry (MeSH)</term>
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<term>Antinéoplasiques d'origine végétale (pharmacologie)</term>
<term>Antioxydants (composition chimique)</term>
<term>Antioxydants (pharmacologie)</term>
<term>Chromatographie en phase liquide (MeSH)</term>
<term>Composés phytochimiques (composition chimique)</term>
<term>Extraits de plantes (composition chimique)</term>
<term>Extraits de plantes (pharmacologie)</term>
<term>Fruit (composition chimique)</term>
<term>Gui (composition chimique)</term>
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<term>Phénols (composition chimique)</term>
<term>Piégeurs de radicaux libres (composition chimique)</term>
<term>Piégeurs de radicaux libres (pharmacologie)</term>
<term>Spectrométrie de masse ESI (MeSH)</term>
<term>Spectrométrie de masse en tandem (MeSH)</term>
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<term>Antioxidants</term>
<term>Free Radical Scavengers</term>
<term>Phenols</term>
<term>Phytochemicals</term>
<term>Plant Extracts</term>
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<term>Antioxidants</term>
<term>Free Radical Scavengers</term>
<term>Plant Extracts</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Fruit</term>
<term>Mistletoe</term>
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<term>Antioxydants</term>
<term>Composés phytochimiques</term>
<term>Extraits de plantes</term>
<term>Fruit</term>
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<term>Piégeurs de radicaux libres</term>
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<term>Tandem Mass Spectrometry</term>
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<front><div type="abstract" xml:lang="en">A new, rapid, sensitive and selective liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) method was developed to determine the content of flavonoid aglycones and phenolic acids in mistletoe berries (<i>Viscum album</i>
 L.) harvested from six different Polish host trees. Additionally, the total phenolic content (TPC) and total flavonoid content (TFC) as well as an antioxidant and antiproliferative activity were evaluated for the first time. The plant material was selectively extracted using ultrasound assisted maceration with methanol/water (8:2) solution. The obtained TPC and TFC results varied from 7.146 to 9.345 mg GA g<sup>-</sup>
¹ and from 1.888 to 2.888 mg Q g<sup>-1</sup>
 of dry extracts, respectively. The LC-ESI-MS/MS analysis demonstrated the highest content of phenolic acids in mistletoe berries from <i>Populus nigra</i>
 'Italica' L. and flavonoid aglycones in mistletoe berries from <i>Tilia cordata</i>
 Mill. (354.45 µg and 5.955 µg per g dry extract, respectively). The moderate antioxidant activity of investigated extracts was obtained. The studies revealed that the examined extracts decreased the proliferation of human colon adenocarcinoma cells line LS180 in a dose-dependent manner without cytotoxicity in the human colon epithelial cell line CCD 841 CoTr. Moreover, the obtained results suggest considerable impact of polyphenols on the anticancer activity of these extracts.</div>
</front>
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<DateCompleted><Year>2017</Year>
<Month>05</Month>
<Day>31</Day>
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<Month>12</Month>
<Day>07</Day>
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<ArticleTitle>LC-ESI-MS/MS Identification of Biologically Active Phenolic Compounds in Mistletoe Berry Extracts from Different Host Trees.</ArticleTitle>
<ELocationID EIdType="pii" ValidYN="Y">E624</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.3390/molecules22040624</ELocationID>
<Abstract><AbstractText>A new, rapid, sensitive and selective liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) method was developed to determine the content of flavonoid aglycones and phenolic acids in mistletoe berries (<i>Viscum album</i>
 L.) harvested from six different Polish host trees. Additionally, the total phenolic content (TPC) and total flavonoid content (TFC) as well as an antioxidant and antiproliferative activity were evaluated for the first time. The plant material was selectively extracted using ultrasound assisted maceration with methanol/water (8:2) solution. The obtained TPC and TFC results varied from 7.146 to 9.345 mg GA g<sup>-</sup>
¹ and from 1.888 to 2.888 mg Q g<sup>-1</sup>
 of dry extracts, respectively. The LC-ESI-MS/MS analysis demonstrated the highest content of phenolic acids in mistletoe berries from <i>Populus nigra</i>
 'Italica' L. and flavonoid aglycones in mistletoe berries from <i>Tilia cordata</i>
 Mill. (354.45 µg and 5.955 µg per g dry extract, respectively). The moderate antioxidant activity of investigated extracts was obtained. The studies revealed that the examined extracts decreased the proliferation of human colon adenocarcinoma cells line LS180 in a dose-dependent manner without cytotoxicity in the human colon epithelial cell line CCD 841 CoTr. Moreover, the obtained results suggest considerable impact of polyphenols on the anticancer activity of these extracts.</AbstractText>
</Abstract>
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</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Virology and Immunology, Maria Curie Skłodowska University, Akademicka 19, 20-033 Lublin, Poland. wojciech.rzeski@poczta.umcs.lublin.pl.</Affiliation>
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<Keyword MajorTopicYN="N">Viscum album L.</Keyword>
<Keyword MajorTopicYN="N">antioxidant activity</Keyword>
<Keyword MajorTopicYN="N">antiproliferative activity</Keyword>
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LC-ESI-MS/MS Identification of Biologically Active Phenolic Compounds in Mistletoe Berry Extracts from Different Host Trees.

LC-ESI-MS/MS Identification of Biologically Active Phenolic Compounds in Mistletoe Berry Extracts from Different Host Trees.

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